Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now.
A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills.
This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.
Edited by:
Gary Evans
Imprint: CRC Press
Country of Publication: United Kingdom
Dimensions:
Height: 254mm,
Width: 178mm,
Weight: 453g
ISBN: 9780367394424
ISBN 10: 0367394421
Pages: 408
Publication Date: 25 September 2019
Audience:
General/trade
,
Professional and scholarly
,
College/higher education
,
ELT Advanced
,
Undergraduate
Format: Paperback
Publisher's Status: Active
The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism. Sample Preparation. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis. Quantitative Mass Spectronomy. Immunoassay in Bioanalysis. Phase I Metabolism. Phase II Enzymes. In vitro Techniques for Investigating Metabolism. Drug–Drug Interactions: an in vitro Approach. Clinical Impact of Drug Interactions. Preclinical Pharmacokinetics. Pharmacokinetic / Pharmacodynamic Modeling in Preclinical Drug Discovery. Toxicokinetics. Protein Binding in Plasma: A Case History of a Highly Protein Bound Drug. Metabolite Identification by Spectroscopy. Whole Body Autoradiography. Radiolabeled Studies in Man. Molecular Biology.
