This is the first serious attempt to synthesize all that became known of glutathione over the last three decades. The book contains an update of glutathione biosynthesis with special emphasis on its regulation in adaptive stress responses. Other chapters review glutathione transport systems and glutathione peroxidases and their differences in substrate specificities and localization. Further contributions center on the diversified roles of different glutathione-S-transferases and the roles of nitrosoglutathione and glutaredoxins - a subfamily of redoxins. The book closes with discussions of the analogous or homologous thiol metabolism in pathogens and the potential suitability of involved enzymes as drug targets.
Key selling features:
Summarizing the way glutathione is involved in stress responses Compiling the multiple ways glutathione affects inflammatory responses Disclosing how glutathione dampens programmed cell death such as ferroptosis Exploring the enigma of how enzymes accelerate glutathione-dependent processes Discussing how detoxification and redox regulation is mediated by glutathionylation Reviewing the ways glutaredoxins catalyze protein disulfide reduction Highlighting the medical impact of glutathione-related metabolic pathways Illustrating the role thiol metabolism of pathogens might play in drug discovery
Chapter 11 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons Attribution (CC-BY) 4.0 license.
Edited by:
Leopold Flohe
Imprint: CRC Press Inc
Country of Publication: United States
Volume: 1
Dimensions:
Height: 234mm,
Width: 156mm,
Weight: 748g
ISBN: 9780815365327
ISBN 10: 0815365322
Series: Oxidative Stress and Disease
Pages: 386
Publication Date: 08 October 2018
Audience:
College/higher education
,
General/trade
,
Primary
,
ELT Advanced
Format: Hardback
Publisher's Status: Active
Contents Series Preface.............................................................................................................xi Editor’s Preface....................................................................................................... xiii Editor Biography......................................................................................................xix List of Contributors .................................................................................................xxi Part I Biosynthesis, Compartmentation, and Transport of Glutathione Chapter 1 Biosynthesis of Glutathione and Its Regulation....................................3 Henry Jay Forman, Hongqiao Zhang, and Terrance J. Kavanagh Chapter 2 Renal Glutathione Transport Systems: Roles in Redox Homeostasis, Cytoprotection, and Bioactivation................................ 35 Lawrence H. Lash Part II Glutathione-Dependent Hydroperoxide Metabolism Chapter 3 The Catalytic Mechanism of Glutathione Peroxidases....................... 53 Laura Orian, Giorgio Cozza, Matilde Maiorino, Stefano Toppo, and Fulvio Ursini Chapter 4 GPx1-Dependent Regulatory Processes in Health and Disease......... 67 Diane E. Handy and Joseph Loscalzo Chapter 5 Glutathione Peroxidase 1 as a Modulator of Insulin Production and Signaling: Implications for Its Dual Role in Diabetes................. 81 Holger Steinbrenner and Lars-Oliver Klotz Chapter 6 GPx2 Role in Physiology and Carcinogenesis....................................95 Anna P. Kipp Chapter 7 GPx4: From Prevention of Lipid Peroxidation to Spermatogenesis and Back................................................................ 111 Matilde Maiorino, Antonella Roveri, and Fulvio Ursini Chapter 8 Thiols, Glutathione, GPx4, and Lipid Metabolism at the Crossroads of Cell Death and Survival............................................. 129 José Pedro Friedmann Angeli, Valerian E. Kagan, and Marcus Conrad Chapter 9 Peroxiredoxin 6 as Glutathione Peroxidase...................................... 143 Yefim Manevich Chapter 10 Glutathione Peroxidases and the Thyroid Gland.............................. 161 Lutz Schomburg Part III Conjugations and Isomerizations Chapter 11 Glutathione Transferases: From the Test Tube to the Cell................ 175 Bengt Mannervik and Birgitta Sjödin Chapter 12 Protein S-glutathionylation and Glutathione S-transferase P............ 201 Kenneth D. Tew Chapter 13 The Role of Glutathione in Biosynthetic Pathways and Regulation of the Eicosanoid Metabolism........................................ 215 Ralf Morgenstern, Leopold Flohé, Jesper Z. Haeggström, and Per-Johan Jakobsson Chapter 14 Nitric Oxide and S-Nitrosoglutathione..............................................227 Iain L. O. Buxton and Scott D. Barnett Part IV The Glutaredoxins Chapter 15 The Catalytic Mechanism of Glutaredoxins..................................... 251 Linda Liedgens and Marcel Deponte Chapter 16 The Role of Glutaredoxins in the Brain............................................263 Carsten Bernd, Anna Dorothee Engelke, Klaudia Lepka, and Lars Bräutigam Part V Glutathione Derivatives and Substitutes in Pathogenic Microorganisms Chapter 17 Biosynthesis of Polyamine–Glutathione Derivatives in Enterobacteria and Kinetoplastida...................................................285 Marcelo A. Comini Chapter 18 Trypanothione Functions in Kinetoplastida......................................307 Martín Hugo, Madia Trujillo, Lucía Piacenza, and Rafael Radi Chapter 19 Mycothiol, a Low-Molecular-Weight Thiol Drafted for Oxidative Stress Defense Duty......................................................... 331 Leonardo Astolfi Rosado, Brandán Pedre, and Joris Messens Chapter 20 Biosynthesis and Functions of Bacillithiol in Firmicutes................. 357 Quach Ngoc Tung, Nico Linzner, Vu Van Loi, and Haike Antelmann Index....................................................................................................................... 379
Leopold Flohé is Professor at the Universidad de la Republica Uruguay in Montevideo, Uruguay. He also Distinguishing Visiting Professor in the Department of Molecular Medicine at the University of Padova in Italy. He has been recognized by PubMed.gov as a Redox Pioneer because has published an article on antioxidant/redox biology, as first author, that has been cited more than 1,000 times, and more than 20 articles have been cited more than 100 times. He obtained the medical doctorate at the Institute of Pharmacology and Toxicology at the University of Tübingen, Germany, in 1968. He held positions in both Academia (Tübingen, Aachen, and Braunschweig, Germany) and industry (Aachen). He is now operating the biotech company MOLISA in Magdeburg, Germany, while teaching as guest professor at the local university. Dr. Flohé is the pioneer who established the selenoprotein nature of glutathione peroxidase (GPx), the first and, for almost 10 years, the only selenoprotein known in animals. His work was pivotal to link the essential trace element selenium to metabolic processes, which led the Food and Drug Administration (FDA) to approve selenium supplementation for humans in 1980, and stimulated selenium biochemistry in general. In recent years, he embarked on investigating how pathogens protect themselves from oxidative killing. His studies on the thiol-dependent hydroperoxide metabolism of trypanosomatids and mycobacteria defined molecular drug targets, paving the way to new therapeutic strategies for neglected diseases affecting the people of developing countries.
