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Mitochondrial Biology

New Perspectives

Derek J. Chadwick Jamie A. Goode

$327.95

Hardback

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English
John Wiley & Sons Inc
12 October 2007
With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.

Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function.

Edited by:   ,
Imprint:   John Wiley & Sons Inc
Country of Publication:   United States
Volume:   287
Dimensions:   Height: 234mm,  Width: 159mm,  Spine: 17mm
Weight:   538g
ISBN:   9780470066577
ISBN 10:   0470066571
Series:   Novartis Foundation Symposia
Pages:   254
Publication Date:  
Audience:   Professional and scholarly ,  Undergraduate
Format:   Hardback
Publisher's Status:   Active

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.  Chairman: David G Nicholls, Buck Institute for Age Research, Novato, USA.

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