Thin Layer Chromatography in Chiral Separations and Analysis

Teresa Kowalska, Joseph Sherma

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English

CRC Press Inc
22 June 2007

Medical research; Chromatography; Life sciences: general issues; Biochemistry; Pharmaceutical technology; Sanitary & municipal engineering

Thin layer chromatography (TLC) is well suited for performing enantioseparations for research as well as larger-scale applications. A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first book to focus solely on the theory, capabilities, and applications of TLC for direct and indirect enantioseparations. The first part of the book examines the fundamental principles of chirality and TLC. It describes the necessary materials, laboratory equipment, procedures, and strategies for the separation, quantification, isolation, and analysis of chiral compounds. The second part evaluates the real-world enantioseparations and densitometric analyses. Emphasizing pharmaceutical applications, the book discusses chiral separation mechanisms and methods for analyzing the chiral purity of diastereoisomers, amino acids, beta-blockers, and NSAIDS. Topics also include commercial stationary phases and chiral modifiers of mobile phases. Thin Layer Chromatography in Chiral Separations and Analysis presents a unified perspective of theory and experimental details underlying the collective developments in the field. The book offers scientists in a variety of disciplines and levels of expertise a complete guide to understanding the current and potential applications of chiral TLC.

Edited by: Teresa Kowalska, Joseph Sherma
Imprint: CRC Press Inc
Country of Publication: United States
Dimensions: Height: 229mm, Width: 152mm, Spine: 29mm
Weight: 703g
ISBN: 9780849343698
ISBN 10: 0849343690
Pages: 436
Publication Date: 22 June 2007
Audience: Professional and scholarly , Professional and scholarly , Professional & Vocational , Undergraduate , Further / Higher Education
Format: Hardback
Publisher's Status: Active

Introduction. Chirality. Commercial Stationary Phases for Enantioseparations. Planar Chromatographic Enantioseparations on Non-commercial CSPs. Planar Chromatographic Enantioseparations on Non-Commercial CCPs. Chiral Modifiers of Mobile Phases. An Overview of the Chiral Separation Mechanisms. Separation of Diastereoisomers by means of TLC. Selected Bottlenecks of Densitometric Detection with Chiral Analytes. Chirality of Pharmaceutical Product Racemates. Chiral Separation of the Selected β-blockers. Chiral Separation of Aminoacid Enantiomers. Chiral Separation of NSAIDs. Determination of Components in Selected Drug Racemates. Chiral Separations using Marfey’s Reagent.

Kowalska, Teresa; Sherma, Joseph

Reviews for Thin Layer Chromatography in Chiral Separations and Analysis

Within Thin Layer Chromatography in Chiral Separations and Analysis the editors succeeded very well in producing a comprehensive, yet accessible, source of information, having won respected specialists in this field. It provides an excellent overview of the subject both in theoretical and practical aspects. -Dr. W. Schwack, University of Hohenheim, in CAMAG Bibliography Service, April 2008 In 15 chapters of the book, written by 24 authors (many with well recognized achievements in the analysis of chiral compounds), all important aspects of the separation and analysis of enantiomers by planar chromatography are covered . . . One advantage of this monograph is the extensive literature cited by the authors, and in most chapters the references contain the full titles of the articles cited . . . publication is very timely. - Edward Soczewinski, in Journal of Chromatographic Science, 2008